Diacylglycerol kinases in cancer
Web1 Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; E-Mail: [email protected] ... Abstract: Diacylglycerol kinases (DGKs) are a diverse family of enzymes that catalyze the conversion of diacylglycerol (DAG), a crucial second messenger of receptor-mediated ... WebDiacylglycerol kinases in cancer. @article{Mrida2024DiacylglycerolKI, title={Diacylglycerol kinases in cancer.}, author={Isabel M{\'e}rida and Pedro Torres-Ayuso and Antonia {\'A}vila-Flores and Javier Arranz-Nicol{\'a}s and Elena Andrada and Mar{\'i}a Tello-Lafoz and Rosa Liebana and Raquel Arcos}, journal={Advances in …
Diacylglycerol kinases in cancer
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WebNov 15, 2015 · DGKα is one of 10 DGK family members that convert diacylglycerol (DAG) to phosphatidic acid (PA), and both DAG and PA are critical lipid second messengers in … WebJun 13, 2013 · After its generation, DAG is actively metabolized into phosphatidic acid by one of the 2 isoforms of diacylglycerol kinases (dgk) present within T cells, dgkα or dgkζ . Previously, we and others observed that deletion of either dgk isoform potentiates DAG-mediated Ras and extracellular signal-regulated kinase (ERK) activation and augments …
WebJan 1, 2024 · The Diacylglycerol kinases (DGK) limit DAG-dependent functions in T lymphocytes and their upregulation in tumor-infiltrating T lymphocytes contribute to limit T cell cytotoxic potential. DGK blockade could reinstate T cell attack on tumors, limiting at the same time tumor cell growth, thanks to the DGK positive input into several oncogenic ...
WebMar 1, 2016 · The α-isozyme enhances the proliferation of cancer cells. However, DGKα facilitates the nonresponsive state of immunity known as T-cell anergy; therefore, DGKα … WebSep 5, 2024 · Novel therapeutic drugs with better anti-cancer effects and fewer side effects are therefore required for patients with unresectable HCC. Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to generate phosphatidic acid, which in turn plays important roles in intracellular signal transduction.
WebOct 13, 2024 · C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes, are present in multiple signaling …
WebOct 16, 2024 · Diacylglycerol (DG) kinase (DGK) phosphorylates DG to generate phosphatidic acid (PA). The α isozyme is activated by Ca2+ through its EF-hand motifs and tyrosine phosphorylation. DGKα is highly … greatlander incubatorWebAug 24, 2015 · PA-generating enzyme expression and/or activity could thus provide a basis for cancer therapies. Diacylglycerol kinase-ζ (DGKζ) is a DGK family enzyme that, by phosphorylating diacylglycerol ... flock wallpaper b\\u0026qWebDiacylglycerol kinases (DGKs) are a family of enzymes that catalyze the metabolism of diacylglycerol (DAG). Two isoforms of DGK, DGKα, and DGKζ, specifically regulate the … great land crabWebJul 1, 2024 · Abstract. Diacylglycerol kinases (DGKs) are integral components of signal transduction cascades that regulate cell biology through phosphorylation of the … flock wallpaper saleWebGarcia-Bermejo, M. L. et al. Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCα. J. Biol. flock wallpaper b\u0026qWebNov 12, 2015 · Abstract. Lipid kinases have largely been neglected as targets in cancer, and an increasing number of reports suggest diacylglycerol kinase alpha (DGKα) may … flock wallpaper designsWebDiacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) DGKalpha isoform is highly expressed in the nuclei of human erythroleukemia cell line K562, and its nuclear activity drives K562 cells through the G1/S transition during cell cycle progression. greatland dome tent 4-6