WebNational Center for Biotechnology Information WebHuman TNF-α ELISA Kit. 碧云天的Human TNF-α ELISA Kit (Human Tumor Necrosis Factor-α Enzyme-Linked ImmunoSorbent Assay Kit),即人肿瘤坏死因子-α酶联免疫吸附检测试剂盒,是一种用于特异性地高灵敏地定量检测人血清、血浆、细胞或组织裂解液、或细胞培养上清液中的TNF-α的试剂盒 ...
Analysis of FasL and TRAIL induced apoptosis pathways in …
WebDec 23, 2010 · The receptors TNF (tumor necrosis factor), Fas (Apo-1, CD95) and TRAILR (TNF-related apoptosis-inducing ligand, Apo-2) are members of the TNF receptor superfamily and share a common internal death domain. Activation occurs by their natural ligands TNFα, FasL (Fas-ligand) and TRAIL . The interaction between receptor and … WebApr 4, 2024 · Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) and Fas Ligand (FasL/TNFSF6), two major cytokines of the TNF (Tumor Necrosis Factor) superfamily, exert their main functions … thinking dice
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WebOct 14, 2014 · Both FasL and TRAIL play a central role in the induction of the cytotoxicity of T and NK cells in infectious diseases and cancer [33,34]. However, a major drawback of targeting Fas as an anti-cancer therapy is that in contrast to TRAIL-R, Fas displays broad tissue expression in both normal and tumor cells raising the risk of severe toxicity ... WebApr 13, 2024 · In contrast, knockout of FasL and inhibition of TRAIL (tumor necrosis factor-related apoptosis-inducing ligands) did not impair cytotoxicity in most conditions. In conclusion, these results indicate the perforin/granzyme pathway as the major pathway to mediate cytotoxicity in CD19-CAR-NK92 cells. WebMay 20, 2024 · TRAIL is a type II transmembrane protein with homology to FasL and TNF. 130 It is expressed by cytotoxic cells such as T cells 131 and NK cells, 132 but it can also be found on other cells such as monocytes, macrophages and dendritic cells. 132, 133 While freshly isolated NK cells do not express detectable levels of TRAIL on their surface ... thinking differently nhs