Web21 de jun. de 2024 · The interaction between hypoxia and RNA N6-methyladenosine (m6A) is an emerging focus of investigation. However, alterations in m6A modifications at distinct hypoxia levels remain uncharacterized in gastric cancer (GC). Unsupervised hierarchical clustering was performed to stratify samples into different clusters. Differentially … Web13 de jan. de 2024 · M6A circXpo6 and m6A circTmtc3 were firstly identified to be downregulated in HPH. Our study firstly identified the transcriptome-wide map of m6A circRNAs in HPH. M6A can influence circRNA–miRNA–mRNA network. ... It is probably because of HIF-dependent and ALKBH5-mediated m 6 A demethylation .
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Web22 de fev. de 2024 · M6A RNA methylation is involved in all stages of RNA life cycle, from RNA processing, nuclear output, translation regulation to RNA degradation, indicating that m6A has various functions affecting RNA metabolism positively or negatively. ... (HIF-1α) and the metastasis of colorectal cancer cells by playing the role of helicase. Web1 de dez. de 2024 · This study was designed to investigate the underlying mechanisms by which MSCs-derived HIF-1α-EVs ameliorate hypoxia-induced β cell death during islet transplantation, and we evidenced that HIF-1α-EVs upregulated YTHDF1 to activate the protective autophagy in a m6A-dependent manner, which further reversed hypoxia … crime dramas tv shows on netflix
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Web13 de abr. de 2024 · N6-methyladenosine (m6A) is the most abundant modification of eukaryotic mRNA and is involved in almost every stage of RNA metabolism. The m6A modification on RNA has been demonstrated to be a regulator of the occurrence and development of a substantial number of diseases, especially cancers. Increasing … Web15 de jan. de 2024 · N6-methyladenosine (m6A) is a dynamic reversible methylation modification of the adenosine N6 position and is the most common chemical epigenetic modification among mRNA post-transcriptional modifications, including methylation, demethylation, and recognition. Post-transcriptional modification involves multiple protein … crime dramas to watch on netflix