WebNov 17, 2024 · IRF8 R294C mice were crossed with C57BL/6 wild-type female for at least three generations to eliminate the vertical transmission of Murine Leukemia Virus (MuLV). Progenies were crossed to generate the mice carrying homozygous alleles for the mutation, and all the mice were used at the age of 8–12 weeks. WebNov 15, 2008 · IRF8 is known to bind to any of 4 distinct target sequences in genes subject to transcriptional activation or repression by IRF8. 29 Studies of the regulatory sequences of Sfpi1, which encodes PU.1, identified 2 possible IRF8 target sites.
Entry - *601565 - INTERFERON REGULATORY FACTOR 8; …
WebAug 24, 2024 · IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation. Deletion of Irf8 leads to massive accumulation of CD11b … WebIFN regulatory factor (IRF) 8 is a transcription factor that has a key role in the cellular response to IFN-γ and is pivotal in myeloid cell differentiation. Whether IRF8 plays a role in the development and function of microglia, the tissue-resident myeloid cells of … how did petya spread
IRF8 Gene - GeneCards IRF8 Protein IRF8 Antibody
In myeloid cells, IRF8 regulates the expression of Bax and Fas to regulate apoptosis. In chronic myelogenous leukemia (CML), IRF8 regulates acid ceramidase to mediate CML apoptosis. IRF8 is highly expressed in myeloid cells and was originally identified in as a critical lineage-specific transcription factor for myeloid cell differentiation, recent studies, however, have shown that IRF8 is also constitutively expressed in non-hematopoietic cancer cells, albeit at a lower leve… WebAug 8, 2024 · IRF8 is a key regulator of innate immunity receptor signaling and plays diverse functions in the development of hematopoietic cells. The effects of IRF8 on hematopoietic stem cells (HSCs) are still unknown. Here, it is demonstrated that IRF8 deficiency results in a decreased number of long-term HSCs (LT-HSCs) in mice. WebMar 10, 2011 · IRF8 is an essential transcriptional regulator of IFN-β expression in monocytes We hypothesized that IRF8, a transcription factor found only in lymphoid and myeloid cells such as macrophages, 24, 32 might be involved. how did petruchio tame katherine